BAIT
NPHS2
AI790225, PDCN, SRN1
nephrosis 2, podocin
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTPRF
AA591035, LAR, LARS, RPTP-LAR, RP23-94L18.2
protein tyrosine phosphatase, receptor type, F
GO Process (20)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- cell migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- negative regulation of cell projection organization [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cytokine-mediated signaling pathway [ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of neurotrophin TRK receptor signaling pathway [ISO]
- negative regulation of receptor binding [ISO]
- nervous system development [ISO]
- neuron projection regeneration [IMP]
- peptidyl-tyrosine dephosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- protein dephosphorylation [ISO]
- regulation of axon regeneration [IMP]
- regulation of neuron projection development [IMP]
- regulation of synapse structure or activity [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
- chondroitin sulfate proteoglycan binding [IPI]
- insulin receptor binding [ISO]
- phosphate ion binding [ISO]
- phosphoprotein phosphatase activity [ISO]
- protein complex binding [IDA]
- protein tyrosine phosphatase activity [ISO]
- receptor tyrosine kinase binding [ISO]
- transmembrane receptor protein tyrosine phosphatase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is found in neurons required for touch sensitivity. ... [more]
Hum. Mol. Genet. Apr. 01, 2016; 25(7);1328-44 [Pubmed: 26792178]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
- Interactor of FLAG-tagged podocin expressed in podocytes
Curated By
- BioGRID