BAIT
NPHS2
AI790225, PDCN, SRN1
nephrosis 2, podocin
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SLC25A4
AU019225, Ant1
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- apoptotic mitochondrial changes [IGI]
- ion transmembrane transport [ISO]
- negative regulation of cardiac muscle cell apoptotic process [ISO]
- negative regulation of mitochondrial membrane permeability involved in apoptotic process [ISO]
- negative regulation of necroptotic process [ISO]
- nucleotide transmembrane transport [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of oxidative phosphorylation uncoupler activity [ISO]
- purine nucleoside transmembrane transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is found in neurons required for touch sensitivity. ... [more]
Hum. Mol. Genet. Apr. 01, 2016; 25(7);1328-44 [Pubmed: 26792178]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
- Interactor of FLAG-tagged podocin expressed in podocytes
Curated By
- BioGRID