BAIT
NPHS2
AI790225, PDCN, SRN1
nephrosis 2, podocin
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
IGF1R
A330103N21Rik, CD221, D930020L01, IGF-1R, hyft
insulin-like growth factor I receptor
GO Process (33)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- axonogenesis [ISO]
- brain development [IMP]
- epidermis development [IMP]
- establishment of cell polarity [ISO]
- exocrine pancreas development [IMP]
- immune response [ISO]
- inactivation of MAPKK activity [ISO]
- insulin-like growth factor receptor signaling pathway [IC, ISO]
- male sex determination [IMP]
- mammary gland development [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- neuron projection development [ISO]
- organ morphogenesis [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, ISO]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of mitosis [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of steroid hormone biosynthetic process [ISO]
- prostate gland epithelium morphogenesis [IMP]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IDA]
- protein tetramerization [ISO]
- regulation of JNK cascade [ISO]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is found in neurons required for touch sensitivity. ... [more]
Hum. Mol. Genet. Apr. 01, 2016; 25(7);1328-44 [Pubmed: 26792178]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
- Interactor of FLAG-tagged podocin expressed in podocytes
Curated By
- BioGRID