BAIT
NPHS2
AI790225, PDCN, SRN1
nephrosis 2, podocin
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ERBB2
Erbb-2, HER-2, HER2, Neu, c-erbB2, c-neu, mKIAA3023, RP23-355L10.8
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
GO Process (35)
GO Function (13)
GO Component (15)
Gene Ontology Biological Process
- cell surface receptor signaling pathway [ISO]
- estrus [ISO]
- glial cell differentiation [ISO]
- heart development [IMP]
- motor neuron axon guidance [IMP]
- myelination [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of immature T cell proliferation in thymus [IMP]
- nervous system development [IMP]
- neuromuscular junction development [IMP]
- oligodendrocyte differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- peripheral nervous system development [IMP, ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of Rho GTPase activity [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase I promoter [ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of translation [ISO]
- protein autophosphorylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of microtubule-based process [ISO]
- response to axon injury [ISO]
- signal transduction [ISO]
- sympathetic nervous system development [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- wound healing [ISO]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase I core binding [ISO]
- glycoprotein binding [ISO]
- growth factor binding [ISO]
- identical protein binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein phosphatase binding [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- transmembrane signaling receptor activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome membrane [ISO]
- integral component of membrane [NAS]
- lateral loop [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic membrane [ISO]
- receptor complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is found in neurons required for touch sensitivity. ... [more]
Hum. Mol. Genet. Apr. 01, 2016; 25(7);1328-44 [Pubmed: 26792178]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
- Interactor of FLAG-tagged podocin expressed in podocytes
Curated By
- BioGRID