BAIT
NPHS2
AI790225, PDCN, SRN1
nephrosis 2, podocin
GO Process (1)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KANK2
AI504612, Ankrd25, BC010245
KN motif and ankyrin repeat domains 2
GO Process (6)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of intracellular estrogen receptor signaling pathway [ISO]
- negative regulation of programmed cell death [ISO]
- negative regulation of stress fiber assembly [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes. Whereas podocin resides at a specialized cell junction at the podocyte slit diaphragm, MEC-2 is found in neurons required for touch sensitivity. ... [more]
Hum. Mol. Genet. Apr. 01, 2016; 25(7);1328-44 [Pubmed: 26792178]
Throughput
- High Throughput
Additional Notes
- High confidence interaction
- Interactor of podocin expressed in native glomeruli
Curated By
- BioGRID