BAIT
BAG1
BAG-1, HAP, RAP46, RP11-326F20.2
BCL2-associated athanogene
GO Process (4)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
SYVN1
DER3, HRD1
synovial apoptosis inhibitor 1, synoviolin
GO Process (5)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum.
Eukaryotic cells eliminate misfolded proteins from the endoplasmic reticulum (ER) via a conserved process termed ER-associated degradation (ERAD). Central regulators of the ERAD system are membrane-bound ubiquitin ligases, which are thought to channel misfolded proteins through the ER membrane during retrotranslocation. Hrd1 and gp78 are mammalian ubiquitin ligases homologous to Hrd1p, an ubiquitin ligase essential for ERAD in Saccharomyces cerevisiae. ... [more]
Mol. Biol. Cell Dec. 01, 2015; 26(24);4438-50 [Pubmed: 26424800]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- CRISPR/Cas9
- the accumulation of ubiquitinated MHC 1-147 and retrotranslocated deglycosylated heavy chain molecules seen in a Bag6 or gp78 knockdown condition was reversed upon depletion of Hrd1 as measured by the split-GFP assay
Curated By
- BioGRID