BAIT
CBLB
AI429560, AI851073, Cbl-b
Casitas B-lineage lymphoma b
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
UBE2D1
UBCH5
ubiquitin-conjugating enzyme E2D 1
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation.
Previously, we demonstrated that CD28 and CTLA-4 signaling control Casitas-B-lineage lymphoma (Cbl)-b protein expression, which is critical for T cell activation and tolerance induction. However, the molecular mechanism(s) of this regulation remains to be elucidated. In this study, we found that Cbl-b fails to undergo tyrosine phosphorylation upon CD3 stimulation because SHP-1 is recruited to and dephosphorylates Cbl-b, whereas CD28 ... [more]
J. Immunol. Nov. 01, 2015; 195(9);4218-27 [Pubmed: 26416283]
Throughput
- Low Throughput
Additional Notes
- E2:Ubc5
Curated By
- BioGRID