BAIT

USP46

ubiquitin specific peptidase 46
UPS Project
GO Process (2)
GO Function (3)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens
PREY

GRIA1

GLUH1, GLUR1, GLURA, GluA1, HBGR1
glutamate receptor, ionotropic, AMPA 1
Homo sapiens

Biochemical Activity (Deubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking.

Huo Y, Khatri N, Hou Q, Gilbert J, Wang G, Man HY

Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPARs) are the primary mediators for inter-neuronal communication and play a crucial role in higher brain functions including learning and memory. Our previous work demonstrated that AMPARs are subject to ubiquitination by the E3 ligase Nedd4, resulting in EPS15-mediated receptor internalization and Ubiquitin (Ub)-proteasome pathway (UPP)-dependent degradation. Protein ubiquitination is a highly dynamic and reversible process, achieved ... [more]

J. Neurochem. Sep. 01, 2015; 134(6);1067-80 [Pubmed: 26077708]

Throughput

  • Low Throughput

Curated By

  • BioGRID