STUB1
Gene Ontology Biological Process
- cellular response to misfolded protein [IMP, ISO]
- misfolded or incompletely synthesized protein catabolic process [IMP, ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO, ISS]
- positive regulation of protein ubiquitination [ISO, ISS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein folding [TAS]
- protein maturation [TAS]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [TAS]
- regulation of glucocorticoid metabolic process [ISO, ISS]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO, ISS, TAS]
- Hsp90 protein binding [ISO, ISS]
- SMAD binding [ISO]
- TPR domain binding [ISO, ISS]
- enzyme binding [ISO]
- heat shock protein binding [TAS]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [IDA]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- ubiquitin-protein transferase activity [ISO, TAS]
- ubiquitin-ubiquitin ligase activity [IDA]
Gene Ontology Cellular Component
CDK5
Gene Ontology Biological Process
- Schwann cell development [IMP]
- apoptotic process [IDA]
- associative learning [IMP]
- axonogenesis [IMP]
- behavioral response to cocaine [IMP]
- calcium ion import [IMP]
- cell migration [IDA, IMP]
- cell-matrix adhesion [IDA]
- central nervous system neuron development [IMP]
- cerebellar cortex development [IMP]
- cerebellar cortex formation [IMP]
- cerebellum development [IMP]
- cerebral cortex development [IMP]
- corpus callosum development [IMP]
- cortical actin cytoskeleton organization [ISO]
- dendrite morphogenesis [IMP]
- exocytosis [ISO]
- forebrain development [IMP]
- hippocampus development [IMP]
- intracellular protein transport [IMP]
- layer formation in cerebral cortex [IMP]
- motor neuron axon guidance [IMP]
- negative regulation of axon extension [IGI]
- negative regulation of cell cycle [IMP]
- negative regulation of neuron death [ISO]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative regulation of proteolysis [ISO]
- negative regulation of synaptic plasticity [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP, ISO]
- neuron differentiation [IMP, ISA, ISO]
- neuron migration [IMP]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- nucleocytoplasmic transport [ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- phosphorylation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein binding [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of receptor activity [IDA]
- protein autophosphorylation [ISO]
- protein localization to synapse [IMP]
- protein phosphorylation [IDA, IGI, IMP, ISO]
- receptor catabolic process [IMP]
- receptor clustering [IMP]
- regulated secretory pathway [ISO]
- regulation of cell cycle [ISO]
- regulation of cell migration [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of postsynaptic membrane potential [IMP]
- regulation of synaptic plasticity [ISO]
- response to cocaine [IMP]
- response to wounding [ISO]
- sensory perception of pain [IMP]
- serine phosphorylation of STAT3 protein [IDA]
- skeletal muscle tissue development [IDA]
- synapse assembly [IMP]
- synaptic transmission, dopaminergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- synaptic vesicle endocytosis [ISO]
- telencephalon development [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
- ErbB-2 class receptor binding [IDA]
- ErbB-3 class receptor binding [IDA]
- acetylcholine receptor activator activity [IDA]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [ISO]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [IPI]
- protein binding [IPI]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [ISO]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cell [IMP]
- cyclin-dependent protein kinase 5 holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [IDA]
- dendrite [ISO]
- filopodium [IDA]
- growth cone [ISO]
- intracellular [IMP]
- lamellipodium [IDA]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleolus [IDA]
- nucleus [IDA, ISO]
- postsynaptic density [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death.
Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase and its dysregulation is implicated in neurodegenerative diseases. Likewise, C-terminus of Hsc70-interacting protein (CHIP) is linked to neurological disorders, serving as an E3 ubiquitin ligase for targeting damaged or toxic proteins for proteasomal degradation. Here, we demonstrate that CHIP is a novel substrate for Cdk5. Cdk5 phosphorylates CHIP at Ser20 via ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 2
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDK5 STUB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1512082 | |
| CDK5 STUB1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 1512080 | |
| STUB1 CDK5 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 1512084 |
Curated By
- BioGRID