BAIT
EVL
AI528774
Ena-vasodilator stimulated phosphoprotein
GO Process (10)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- actin filament-based movement [NAS]
- actin nucleation [NAS]
- actin polymerization or depolymerization [IDA]
- axon guidance [NAS]
- barbed-end actin filament capping [NAS]
- negative regulation of epithelial cell migration [ISO]
- negative regulation of ruffle assembly [ISO]
- platelet activation [NAS]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of stress fiber assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The E3Â Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.
Neuronal growth cone filopodia contain guidance receptors and contribute to axon guidance; however, the mechanism by which the guidance cue netrin increases filopodia density is unknown. Here, we demonstrate that TRIM9, an E3 ubiquitin ligase that localizes to filopodia tips and binds the netrin receptor DCC, interacts with and ubiquitinates the barbed-end polymerase VASP to modulate filopodial stability during netrin-dependent ... [more]
Dev. Cell Dec. 21, 2015; 35(6);698-712 [Pubmed: 26702829]
Throughput
- Low Throughput
Additional Notes
- source of EVL unclear
Related interactions
Curated By
- BioGRID