RIPK2
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IMP]
- T cell proliferation [IMP]
- T cell receptor signaling pathway [IMP]
- adaptive immune response [IMP]
- cellular response to lipopolysaccharide [IMP]
- cellular response to lipoteichoic acid [IMP]
- cellular response to muramyl dipeptide [ISO]
- cellular response to peptidoglycan [IMP]
- defense response to Gram-positive bacterium [IMP]
- innate immune response [IMP, ISO]
- lipopolysaccharide-mediated signaling pathway [IMP]
- nucleotide-binding oligomerization domain containing 1 signaling pathway [IMP]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IMP, ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T-helper 1 cell differentiation [IMP]
- positive regulation of T-helper 1 type immune response [IMP]
- positive regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of apoptotic process [IDA]
- positive regulation of chemokine production [IMP]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of immature T cell proliferation [IMP]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of stress-activated MAPK cascade [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- response to exogenous dsRNA [IMP]
- response to interleukin-1 [IMP]
- response to interleukin-12 [IMP]
- response to interleukin-18 [IMP]
- toll-like receptor 2 signaling pathway [ISO]
- toll-like receptor 4 signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYLD
Gene Ontology Biological Process
- necroptotic process [IGI]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [IBA, ISO]
- negative regulation of T cell differentiation [IDA]
- negative regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- protein K63-linked deubiquitination [IBA, ISO]
- protein deubiquitination [IMP]
- proteolysis [IBA]
- regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of mitotic cell cycle [IBA, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages.
Upon infection with intracellular bacteria, nucleotide oligomerization domain protein 2 recognizes bacterial muramyl dipeptide and binds, subsequently, to receptor-interacting serine/threonine kinase 2 (RIPK2), which activates immune responses via the nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) and extracellular signal-regulated kinase (ERK) pathways. Activation of RIPK2 depends on its K63 ubiquitination by E3 ligases, whereas the deubiquitinating enzyme A20 ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CYLD RIPK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1512319 |
Curated By
- BioGRID