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BAIT

PRDM1

BLIMP1, PRDI-BF1, RP1-134E15.1

PR domain containing 1, with ZNF domain

GO Process (1)

GO Function (4)

GO Component (1)

Gene Ontology Biological Process

negative regulation of transcription from RNA polymerase II promoter [IDA]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
protein binding [IPI]
sequence-specific DNA binding transcription factor activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

HSPA9

CRP40, CSA, GRP-75, GRP75, HEL-S-124m, HSPA9B, MOT, MOT2, MTHSP75, PBP74

heat shock 70kDa protein 9 (mortalin)

GO Process (3)

GO Function (4)

GO Component (5)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

negative regulation of apoptotic process [TAS]

protein targeting to mitochondrion [TAS]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]
ubiquitin protein ligase binding [IPI]
unfolded protein binding [TAS]

Gene Ontology Cellular Component

cytoplasm [TAS]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

mitochondrial nucleoid [IDA]

mitochondrion [IDA, TAS]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells.

Hung KH, Su ST, Chen CY, Hsu PH, Huang SY, Wu WJ, Chen MM, Chen HY, Wu PC, Lin FR, Tsai MD, Lin KI

The transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) has crucial roles in the control of plasma cell differentiation and in maintaining survival of plasma cells. However, how Blimp-1 ensures the survival of plasma cell malignancy, multiple myeloma (MM), has remained elusive. Here we identified Aiolos, an anti-apoptotic transcription factor of MM cells, as a Blimp-1-interacting protein by mass spectrometry. ChIP ... [more]

Cell Death Differ. Jan. 29, 2016; 0(0); [Pubmed: 26823144]

Throughput

Low Throughput

Additional Notes

Figure S1

Curated By

BioGRID