NF2
Gene Ontology Biological Process
- Schwann cell proliferation [IMP]
- actin cytoskeleton organization [IMP]
- negative regulation of DNA replication [IMP]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell migration [TAS]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell-cell adhesion [IDA]
- negative regulation of cell-matrix adhesion [TAS]
- negative regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- positive regulation of stress fiber assembly [IMP]
- regulation of hippo signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AMOTL2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.
Merlin has broad tumor-suppressor functions as its mutations have been identified in multiple benign tumors and malignant cancers. In all schwannomas, the majority of meningiomas and 1/3 of ependymomas Merlin loss is causative. In neurofibromatosis type 2, a dominantly inherited tumor disease because of the loss of Merlin, patients suffer from multiple nervous system tumors and die on average around ... [more]
Throughput
- High Throughput
Additional Notes
- Table S1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AMOTL2 NF2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.96 | BioGRID | - | |
| NF2 AMOTL2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9237 | BioGRID | 3159862 | |
| NF2 AMOTL2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| AMOTL2 NF2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2715384 |
Curated By
- BioGRID