BAIT
KSR1
AW492498, B-KSR1, D11Bhm183e, D11Bhm184e, Ksr, RSU2, hb, RP23-12I13.1
kinase suppressor of ras 1
GO Process (1)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
YWHAG
14-3-3GAMMA, PPP1R170
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
GO Process (11)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- apoptotic process [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- membrane organization [TAS]
- mitotic cell cycle [TAS]
- negative regulation of protein kinase activity [NAS]
- negative regulation of protein serine/threonine kinase activity [NAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of neuron differentiation [IMP]
- regulation of signal transduction [NAS]
- regulation of synaptic plasticity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.
Merlin has broad tumor-suppressor functions as its mutations have been identified in multiple benign tumors and malignant cancers. In all schwannomas, the majority of meningiomas and 1/3 of ependymomas Merlin loss is causative. In neurofibromatosis type 2, a dominantly inherited tumor disease because of the loss of Merlin, patients suffer from multiple nervous system tumors and die on average around ... [more]
Oncogene Nov. 09, 2015; 0(0); [Pubmed: 26549023]
Throughput
- High Throughput
Additional Notes
- Table S1
Curated By
- BioGRID