BAIT

KSR1

AW492498, B-KSR1, D11Bhm183e, D11Bhm184e, Ksr, RSU2, hb, RP23-12I13.1
kinase suppressor of ras 1
GO Process (1)
GO Function (4)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

LRRC47

RP1-286D6.3
leucine rich repeat containing 47
GO Process (0)
GO Function (2)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.

Zhou L, Lyons-Rimmer J, Ammoun S, Mueller J, Lasonder E, Sharma V, Ercolano E, Hilton D, Taiwo I, Barczyk M, Hanemann CO

Merlin has broad tumor-suppressor functions as its mutations have been identified in multiple benign tumors and malignant cancers. In all schwannomas, the majority of meningiomas and 1/3 of ependymomas Merlin loss is causative. In neurofibromatosis type 2, a dominantly inherited tumor disease because of the loss of Merlin, patients suffer from multiple nervous system tumors and die on average around ... [more]

Oncogene Nov. 09, 2015; 0(0); [Pubmed: 26549023]

Throughput

  • High Throughput

Additional Notes

  • Table S1

Curated By

  • BioGRID