BAIT

KPNA1

AW494490, IPOA5, NPI1, Rch2, mSRP1
karyopherin (importin) alpha 1
GO Process (1)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

CBX1

CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
chromobox homolog 1
GO Process (0)
GO Function (4)
GO Component (5)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box.

Moriyama T, Sangel P, Yamaguchi H, Obuse C, Miyamoto Y, Oka M, Yoneda Y

Tripartite motif-containing 28 (TRIM28) is a transcription regulator, which forms a repressor complex containing heterochromatin protein 1 (HP1). Here, we report identification of a nuclear localization signal (NLS) within the 462-494 amino acid region of TRIM28 that overlaps with its HP1 binding site, HP1 box. GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin α subtypes ... [more]

Biochem. Biophys. Res. Commun. Jul. 03, 2015; 462(3);201-7 [Pubmed: 25960296]

Throughput

  • Low Throughput

Additional Notes

  • Figure 3

Curated By

  • BioGRID