BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
USP7
2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, Hausp
ubiquitin specific peptidase 7
GO Process (12)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- histone deubiquitination [IBA]
- maintenance of DNA methylation [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, ISO]
- proteolysis [IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of protein stability [ISO]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of transcription, DNA-templated [IBA]
- transcription-coupled nucleotide-excision repair [IBA, ISO]
Gene Ontology Molecular Function- cysteine-type endopeptidase activity [IMP, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin thiolesterase activity [IDA, ISO]
- ubiquitin-specific protease activity [IDA, ISO]
- cysteine-type endopeptidase activity [IMP, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin thiolesterase activity [IDA, ISO]
- ubiquitin-specific protease activity [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Posttranslational modifications are central to the spatial and temporal regulation of protein function. Among others, phosphorylation and ubiquitylation are known to regulate proximal T-cell receptor (TCR) signaling. Here we used a systematic and unbiased approach to uncover deubiquitylating enzymes (DUBs) that participate during TCR signaling in primary mouse T lymphocytes. Using a C-terminally modified vinyl methyl ester variant of ubiquitin ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 09, 2016; 113(6);E705-14 [Pubmed: 26811477]
Throughput
- High Throughput
Additional Notes
- Deubiquitylating enzymes retrieved by HA-Ub-VME
Curated By
- BioGRID