BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CYLD
2010013M14Rik, 2900009M21Rik, C130039D01Rik, CDMT, CYLD1, EAC, mKIAA0849
cylindromatosis (turban tumor syndrome)
GO Process (13)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- necroptotic process [IGI]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [IBA, ISO]
- negative regulation of T cell differentiation [IDA]
- negative regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- protein K63-linked deubiquitination [IBA, ISO]
- protein deubiquitination [IMP]
- proteolysis [IBA]
- regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of mitotic cell cycle [IBA, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Posttranslational modifications are central to the spatial and temporal regulation of protein function. Among others, phosphorylation and ubiquitylation are known to regulate proximal T-cell receptor (TCR) signaling. Here we used a systematic and unbiased approach to uncover deubiquitylating enzymes (DUBs) that participate during TCR signaling in primary mouse T lymphocytes. Using a C-terminally modified vinyl methyl ester variant of ubiquitin ... [more]
Proc. Natl. Acad. Sci. U.S.A. Feb. 09, 2016; 113(6);E705-14 [Pubmed: 26811477]
Throughput
- High Throughput
Additional Notes
- Deubiquitylating enzymes retrieved by HA-Ub-VME
Related interactions
Curated By
- BioGRID