BAIT
RHOU
ARHU, CDC42L1, G28K, WRCH1, hG28K, SB128
ras homolog family member U
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLEK
P47
pleckstrin
GO Process (25)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- blood coagulation [TAS]
- cell projection organization [IDA]
- cortical actin cytoskeleton organization [IDA]
- hematopoietic progenitor cell differentiation [IEP]
- integrin-mediated signaling pathway [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of calcium-mediated signaling [NAS]
- negative regulation of inositol phosphate biosynthetic process [IDA]
- phosphatidylinositol metabolic process [IDA]
- phospholipase C-inhibiting G-protein coupled receptor signaling pathway [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP, ISS]
- platelet degranulation [IEP, TAS]
- positive regulation of actin filament bundle assembly [IDA]
- positive regulation of actin filament depolymerization [IDA]
- positive regulation of inositol-polyphosphate 5-phosphatase activity [IDA]
- positive regulation of integrin activation [ISS]
- positive regulation of platelet activation [ISS]
- protein kinase C signaling [ISS]
- protein secretion by platelet [ISS]
- regulation of cell diameter [IDA]
- ruffle organization [IDA]
- thrombin receptor signaling pathway [IDA]
- vesicle docking involved in exocytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion.
P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly higher in high-grade human breast cancer patient samples, whereas depletion of PAK4 modifies cell adhesion dynamics of breast cancer cells. Surprisingly, systematic analysis of PAK4 functionality revealed that PAK4-driven adhesion turnover is neither dependent ... [more]
J. Cell Biol. Nov. 23, 2015; 211(4);863-79 [Pubmed: 26598620]
Throughput
- High Throughput
Additional Notes
- Table S1
- identified via protein microarray
Curated By
- BioGRID