BAIT
RHOU
ARHU, CDC42L1, G28K, WRCH1, hG28K, SB128
ras homolog family member U
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CHRNA4
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal)
GO Process (21)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- B cell activation [ISS]
- DNA repair [IMP]
- action potential [ISS]
- behavioral response to nicotine [IMP]
- calcium ion transport [ISS]
- cation transmembrane transport [IDA, TAS]
- cognition [IMP]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- membrane depolarization [ISS]
- neurological system process [IMP]
- regulation of dopamine secretion [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of membrane potential [ISS]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- sensory perception of pain [ISS]
- signal transduction [IDA]
- synaptic transmission [NAS, TAS]
- synaptic transmission, cholinergic [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion.
P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly higher in high-grade human breast cancer patient samples, whereas depletion of PAK4 modifies cell adhesion dynamics of breast cancer cells. Surprisingly, systematic analysis of PAK4 functionality revealed that PAK4-driven adhesion turnover is neither dependent ... [more]
J. Cell Biol. Nov. 23, 2015; 211(4);863-79 [Pubmed: 26598620]
Throughput
- High Throughput
Additional Notes
- Table S1
- identified via protein microarray
Curated By
- BioGRID