BAIT

RHOU

ARHU, CDC42L1, G28K, WRCH1, hG28K, SB128
ras homolog family member U
GO Process (4)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

S100A4

18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98
S100 calcium binding protein A4
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion.

Dart AE, Box GM, Court W, Gale ME, Brown JP, Pinder SE, Eccles SA, Wells CM

P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion disassembly in a kinase-dependent manner. We found that PAK4 expression is significantly higher in high-grade human breast cancer patient samples, whereas depletion of PAK4 modifies cell adhesion dynamics of breast cancer cells. Surprisingly, systematic analysis of PAK4 functionality revealed that PAK4-driven adhesion turnover is neither dependent ... [more]

J. Cell Biol. Nov. 23, 2015; 211(4);863-79 [Pubmed: 26598620]

Throughput

  • High Throughput

Additional Notes

  • Table S1
  • identified via protein microarray

Curated By

  • BioGRID