BAIT

MDM2

1700007J15Rik, AA415488, Mdm-2
transformed mouse 3T3 cell double minute 2
GO Process (24)
GO Function (9)
GO Component (9)
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.

Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama KI

MDM2 mediates the ubiquitylation and thereby triggers the proteasomal degradation of the tumor suppressor protein p53. However, genetic evidence suggests that MDM2 contributes to multiple regulatory networks independently of p53 degradation. We have now identified the DEAD-box RNA helicase DDX24 as a nucleolar protein that interacts with MDM2. DDX24 was found to bind to the central region of MDM2, resulting ... [more]

Mol. Cell. Biol. Sep. 01, 2014; 34(17);3321-40 [Pubmed: 24980433]

Throughput

  • High Throughput

Curated By

  • BioGRID