DNMT3L
Gene Ontology Biological Process
Gene Ontology Molecular Function
HAND1
Gene Ontology Biological Process
- angiogenesis [ISS]
- blastocyst development [IEP]
- cardiac left ventricle formation [IMP]
- cardiac right ventricle formation [IMP]
- cardiac septum morphogenesis [IMP]
- embryonic heart tube development [ISS]
- heart development [ISS]
- heart looping [ISS]
- negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IEP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [NAS]
- transcription coactivator activity [IC, IDA]
- transcription corepressor activity [IC]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [NAS]
- transcription coactivator activity [IC, IDA]
- transcription corepressor activity [IC]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NFκB complex in the (de-)methylation of TRAF1.
DNMT3L i.e. DNA (cytosine-5)-methyltransferase 3-like protein, is devoid of cytosine methyltransferase activity, despite clear homology to DNMT3A and DNMT3B, due to the mutation of key catalytic residues. However, DNMT3L participates in de novo methylation reactions through its direct interaction with DNMT3A and DNMT3B. In the present study, we investigated if DNMT3L interacts also directly with transcription factors (TFs). Using TF ... [more]
Throughput
- Low Throughput
Additional Notes
- Panomics TranSignal TF Protein Arrays
- Table 1
Curated By
- BioGRID