JAG1
Gene Ontology Biological Process
- Notch signaling involved in heart development [ISO]
- Notch signaling pathway [IMP, ISO]
- T cell mediated immunity [ISO]
- aorta morphogenesis [ISO]
- auditory receptor cell differentiation [IMP, ISO]
- blood vessel remodeling [ISO]
- camera-type eye development [ISO]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISO]
- cardiac right ventricle morphogenesis [ISO]
- cardiac septum morphogenesis [ISO]
- cell fate determination [NAS]
- ciliary body morphogenesis [ISO]
- endocardial cushion cell development [ISO]
- inner ear development [ISO]
- morphogenesis of an epithelial sheet [ISO]
- negative regulation of cell differentiation [IDA, ISO]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of stem cell differentiation [ISO]
- neuronal stem cell maintenance [ISO]
- organ morphogenesis [ISO]
- organ regeneration [IEP]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of myeloid cell differentiation [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- pulmonary artery morphogenesis [ISO]
- pulmonary valve morphogenesis [ISO]
- regulation of cell proliferation [IMP]
- response to muramyl dipeptide [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APBB1
Gene Ontology Biological Process
- axonogenesis [NAS]
- cell cycle arrest [ISS]
- cellular response to DNA damage stimulus [IDA]
- histone H4 acetylation [ISS]
- negative regulation of cell growth [ISS]
- negative regulation of thymidylate synthase biosynthetic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [ISS]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1.
Fe65 is a highly conserved adaptor protein that interacts with several binding partners. Fe65 binds proteins to mediate various cellular processes. But the interacting partner and the regulatory mechanisms controlled by Fe65 are largely unknown. In this study, we found that Fe65 interacts with the C-terminus of Jagged1. Furthermore, Fe65 negatively regulates AP1-mediated Jagged1 intercellular domain transactivation in a Tip60-independent ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| JAG1 APBB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1513624 | |
| APBB1 JAG1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1513627 |
Curated By
- BioGRID