NEURL1
Gene Ontology Biological Process
- cellular response to amino acid stimulus [ISS]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- nervous system development [TAS]
- positive regulation of apoptotic process [IDA]
- positive regulation of dendritic spine development [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISS]
- positive regulation of synapse maturation [ISS]
- protein monoubiquitination [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APBB1
Gene Ontology Biological Process
- axonogenesis [NAS]
- cell cycle arrest [ISS]
- cellular response to DNA damage stimulus [IDA]
- histone H4 acetylation [ISS]
- negative regulation of cell growth [ISS]
- negative regulation of thymidylate synthase biosynthetic process [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription, DNA-templated [ISS]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1.
Fe65 is a highly conserved adaptor protein that interacts with several binding partners. Fe65 binds proteins to mediate various cellular processes. But the interacting partner and the regulatory mechanisms controlled by Fe65 are largely unknown. In this study, we found that Fe65 interacts with the C-terminus of Jagged1. Furthermore, Fe65 negatively regulates AP1-mediated Jagged1 intercellular domain transactivation in a Tip60-independent ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 6
Curated By
- BioGRID