LMAN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [IDA, ISO]
- cell [TAS]
- cytoplasm [TAS]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum-Golgi intermediate compartment [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO]
- intracellular [TAS]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- sarcomere [IDA]
UBXN2A
Gene Ontology Biological Process
- Golgi organization [IBA]
- autophagic vacuole assembly [IBA]
- membrane fusion [IBA]
- nuclear envelope reassembly [IBA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- regulation of catalytic activity [IBA]
- regulation of gene expression [ISO]
- regulation of protein catabolic process [IDA]
- regulation of protein ubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP.
Neuronal nicotinic acetylcholine receptors (nAChRs) containing the α3 subunit are known for their prominent role in normal ganglionic transmission while their involvement in the mechanisms underlying nicotine addiction and smoking-related disease has been emerging only in recent years. The amount of information available on the maturation and trafficking of α3-containing nAChRs is limited. We previously showed that UBXN2A is a ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 5
Curated By
- BioGRID