TOPORS
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- maintenance of protein location in nucleus [ISO]
- positive regulation of transcription, DNA-templated [IGI]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K48-linked ubiquitination [ISO]
- protein localization to nucleus [ISO]
- protein monoubiquitination [ISO]
- protein sumoylation [ISO]
- regulation of cell proliferation [IDA]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PSMC1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.
The significance of the ubiquitin-proteasome system (UPS) for protein degradation has been highlighted in the context of neurodegenerative diseases, including retinal dystrophies. TOPORS, a dual E3 ubiquitin and SUMO1 ligase, forms a component of the UPS and selected substrates for its enzymatic activities, such as DJ-1/PARK7 and APOBEC2, are important for neuronal as well as retinal homeostasis, respectively. TOPORS is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID