BAIT
ABCG1
ABC8, WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1
GO Process (23)
GO Function (13)
GO Component (9)
Gene Ontology Biological Process
- amyloid precursor protein catabolic process [IDA]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- detection of hormone stimulus [NAS]
- glycoprotein transport [IDA]
- high-density lipoprotein particle remodeling [ISS]
- intracellular cholesterol transport [IMP]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle remodeling [ISS]
- negative regulation of cholesterol storage [TAS]
- negative regulation of macrophage derived foam cell differentiation [TAS]
- phospholipid efflux [IMP]
- phospholipid homeostasis [IMP]
- positive regulation of cholesterol biosynthetic process [ISS]
- regulation of cholesterol esterification [ISS]
- regulation of transcription, DNA-templated [ISS]
- response to lipid [IDA]
- response to organic substance [IDA]
- reverse cholesterol transport [ISS]
- small molecule metabolic process [TAS]
- toxin transport [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA, TAS]
- glycoprotein transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sterol-transporting ATPase activity [IDA]
- toxin transporter activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA, TAS]
- glycoprotein transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sterol-transporting ATPase activity [IDA]
- toxin transporter activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP1A1
Nkaa1b
ATPase, Na+/K+ transporting, alpha 1 polypeptide
GO Process (27)
GO Function (13)
GO Component (19)
Gene Ontology Biological Process
- ATP catabolic process [ISO, TAS]
- cardiac muscle contraction [TAS]
- cellular potassium ion homeostasis [ISO]
- cellular response to mechanical stimulus [IDA]
- cellular response to steroid hormone stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- dephosphorylation [ISO]
- energy coupled proton transmembrane transport, against electrochemical gradient [TAS]
- membrane hyperpolarization [IMP]
- membrane repolarization [ISO]
- negative regulation of glucocorticoid biosynthetic process [ISO]
- negative regulation of heart contraction [ISO]
- positive regulation of heart contraction [ISO]
- positive regulation of striated muscle contraction [ISO]
- potassium ion import [IDA, ISO]
- potassium ion transmembrane transport [ISO]
- potassium ion transport [IDA]
- regulation of blood pressure [ISO]
- regulation of cardiac muscle cell contraction [IMP]
- regulation of sodium ion transport [IDA]
- regulation of the force of heart contraction [ISO]
- relaxation of cardiac muscle [TAS]
- response to drug [ISO]
- response to glycoside [ISO]
- sodium ion export from cell [ISO]
- sodium ion transmembrane transport [IDA, ISO]
- sodium ion transport [IDA]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ankyrin binding [IPI]
- chaperone binding [IDA, ISO]
- phosphatase activity [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- sodium ion binding [IDA]
- sodium:potassium-exchanging ATPase activity [IDA, ISO]
- steroid hormone binding [ISO]
- ADP binding [IDA]
- ATP binding [IDA]
- ankyrin binding [IPI]
- chaperone binding [IDA, ISO]
- phosphatase activity [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- potassium ion binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- sodium ion binding [IDA]
- sodium:potassium-exchanging ATPase activity [IDA, ISO]
- steroid hormone binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- T-tubule [IDA, ISO]
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- caveola [IDA]
- endoplasmic reticulum [IDA]
- endosome [IDA]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISS]
- intercalated disc [IDA]
- membrane [IDA, ISO]
- membrane raft [IDA]
- myelin sheath [ISO]
- neuronal postsynaptic density [ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- sodium:potassium-exchanging ATPase complex [IDA, ISO]
- vesicle [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.
The ATP-binding cassette transporter ABCG1 has an essential role in cellular cholesterol homeostasis, and dysregulation has been associated with a number of high burden diseases. Previous studies reported that ABCG1 is ubiquitinated and degraded via the ubiquitin proteasome system. However, so far the molecular mechanism, including the identity of any of the rate-limiting ubiquitination enzymes, or E3 ligases, is unknown. ... [more]
J. Biol. Chem. Oct. 02, 2015; 290(40);24604-13 [Pubmed: 26296893]
Throughput
- High Throughput
Curated By
- BioGRID