BAIT
ABCG1
ABC8, WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1
GO Process (23)
GO Function (13)
GO Component (9)
Gene Ontology Biological Process
- amyloid precursor protein catabolic process [IDA]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- detection of hormone stimulus [NAS]
- glycoprotein transport [IDA]
- high-density lipoprotein particle remodeling [ISS]
- intracellular cholesterol transport [IMP]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle remodeling [ISS]
- negative regulation of cholesterol storage [TAS]
- negative regulation of macrophage derived foam cell differentiation [TAS]
- phospholipid efflux [IMP]
- phospholipid homeostasis [IMP]
- positive regulation of cholesterol biosynthetic process [ISS]
- regulation of cholesterol esterification [ISS]
- regulation of transcription, DNA-templated [ISS]
- response to lipid [IDA]
- response to organic substance [IDA]
- reverse cholesterol transport [ISS]
- small molecule metabolic process [TAS]
- toxin transport [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA, TAS]
- glycoprotein transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sterol-transporting ATPase activity [IDA]
- toxin transporter activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA, TAS]
- glycoprotein transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- sterol-transporting ATPase activity [IDA]
- toxin transporter activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
ACO2
aconitase 2, mitochondrial
GO Process (3)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.
The ATP-binding cassette transporter ABCG1 has an essential role in cellular cholesterol homeostasis, and dysregulation has been associated with a number of high burden diseases. Previous studies reported that ABCG1 is ubiquitinated and degraded via the ubiquitin proteasome system. However, so far the molecular mechanism, including the identity of any of the rate-limiting ubiquitination enzymes, or E3 ligases, is unknown. ... [more]
J. Biol. Chem. Oct. 02, 2015; 290(40);24604-13 [Pubmed: 26296893]
Throughput
- High Throughput
Curated By
- BioGRID