BAIT
EID1
C15orf3, CRI1, EID-1, IRO45620, PTD014, RBP21, PNAS-22
EP300 interacting inhibitor of differentiation 1
GO Process (4)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PFKP
ATP-PFK, PFK-C, PFK-P, PFKF, RP11-298E9.2
phosphofructokinase, platelet
GO Process (5)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.
EP300-interacting inhibitor of differentiation 1 (EID1) belongs to a protein family implicated in the control of transcription, differentiation, DNA repair, and chromosomal maintenance. EID1 has a very short half-life, especially in G0 cells. We discovered that EID1 contains a peptidic, modular degron that is necessary and sufficient for its polyubiquitylation and proteasomal degradation. We found that this degron is recognized ... [more]
Proc. Natl. Acad. Sci. U.S.A. Dec. 15, 2015; 112(50);15372-7 [Pubmed: 26631746]
Throughput
- High Throughput
Curated By
- BioGRID