BAIT
CHAF1A
AL023013, AL024058, CAF-1, Cac1p
chromatin assembly factor 1, subunit A (p150)
GO Process (3)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CTNNA1
2010010M04Rik, AA517462, AI988031, Catna1
catenin (cadherin associated protein), alpha 1
GO Process (15)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- apical junction assembly [IMP]
- cellular protein localization [IMP]
- cellular response to indole-3-methanol [ISO]
- epithelial cell-cell adhesion [IMP]
- establishment or maintenance of cell polarity [IMP]
- gap junction assembly [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell motility [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of integrin-mediated signaling pathway [IMP]
- negative regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of smoothened signaling pathway [IGI]
- protein heterooligomerization [ISO]
- regulation of cell proliferation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic identification of factors for provirus silencing in embryonic stem cells.
Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), sumoylation factors (Sumo2/Ube2i/Sae1/Uba2/Senp6), and chromatin modifiers (Trim28/Eset/Atf7ip) are key determinants that establish provirus silencing. RNA-seq analysis uncovered the roles of Chaf1a/b and ... [more]
Cell Sep. 24, 2015; 163(1);230-45 [Pubmed: 26365490]
Throughput
- High Throughput
Additional Notes
- Figure 7
Curated By
- BioGRID