BAIT

PES1

PES

pescadillo ribosomal biogenesis factor 1

GO Process (6)

GO Function (2)

GO Component (7)

Gene Ontology Biological Process

cell proliferation [IMP, NAS]

maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]

rRNA processing [IMP]

regulation of cell cycle [IMP]

ribosomal large subunit biogenesis [IC]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

PeBoW complex [IDA]

cytoplasm [IDA]

nucleolus [IDA]

nucleoplasm [IDA]

preribosome, large subunit precursor [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ZC3HAV1

ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, PRO1677

zinc finger CCCH-type, antiviral 1

GO Process (7)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

negative regulation of viral genome replication [IDA]

positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]

positive regulation of RIG-I signaling pathway [IMP]

positive regulation of interferon-alpha production [IDA]

positive regulation of interferon-beta production [IDA]

positive regulation of mRNA catabolic process [IDA]

response to virus [IDA]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

cytoplasm [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex.

Kellner M, Rohrmoser M, Forne I, Voss K, Burger K, Muehl B, Gruber-Eber A, Kremmer E, Imhof A, Eick D

PeBoW, a trimeric complex consisting of pescadillo (Pes1), block of proliferation (Bop1), and the WD repeat protein 12 (WDR12), is essential for processing and maturation of mammalian 5.8S and 28S ribosomal RNAs. Applying a mass spectrometric analysis, we identified the DEAD-box helicase DDX27 as stably associated factor of the PeBoW-complex. DDX27 interacts with the PeBoW-complex via an evolutionary conserved FÃ—F ... [more]

Exp. Cell Res. May. 15, 2015; 334(1);146-59 [Pubmed: 25825154]

Throughput

Low Throughput

Curated By

BioGRID