BAIT
CEBPA
C/ebpalpha, CBF-A, Cebp
CCAAT/enhancer binding protein (C/EBP), alpha
GO Process (29)
GO Function (16)
GO Component (6)
Gene Ontology Biological Process
- brown fat cell differentiation [IDA]
- cell maturation [IMP]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- cholesterol metabolic process [IMP]
- cytokine-mediated signaling pathway [NAS]
- embryonic placenta development [IGI]
- fat cell differentiation [IDA]
- inner ear development [IDA]
- liver development [IMP]
- lung development [IMP]
- macrophage differentiation [IMP]
- mitochondrion organization [IMP]
- myeloid cell differentiation [IDA]
- negative regulation of cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of fat cell differentiation [IDA, ISO]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase III promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, ISO, NAS]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [ISO, NAS]
- urea cycle [IDA]
- white fat cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, NAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA, ISO]
- HMG box domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, NAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
RPS4X
Rps4, Rps4-1, RP23-331B22.2
ribosomal protein S4, X-linked
GO Process (2)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational isoform, termed p30, represents the most common type of CEBPA mutation in AML. The molecular mechanisms underlying p30-mediated transformation remain incompletely understood. We show that C/EBPα p30, but not the normal p42 isoform, preferentially interacts ... [more]
Nat. Chem. Biol. Aug. 01, 2015; 11(8);571-8 [Pubmed: 26167872]
Throughput
- High Throughput
Additional Notes
- p30 isoform
Curated By
- BioGRID