BAIT
MEX3C
MEX-3C, RKHD2, RNF194, BM-013
mex-3 RNA binding family member C
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
AIFM1
AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, RP3-438D16.2
apoptosis-inducing factor, mitochondrion-associated, 1
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA catabolic process [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [IMP]
- chromosome condensation [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- mitochondrial respiratory chain complex I assembly [IMP]
- neuron differentiation [IDA]
- positive regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation of mRNAs through the action of a newly identified family of RNA-binding E3 ubiquitin ligases. How ubiquitin regulates mRNA decay remains unclear. Here, we identify a new role for ubiquitin in regulating deadenylation, the initial ... [more]
Nat Commun Oct. 17, 2015; 6(0);8670 [Pubmed: 26471122]
Throughput
- High Throughput
Additional Notes
- Table S1
Curated By
- BioGRID