BAIT
MEX3C
MEX-3C, RKHD2, RNF194, BM-013
mex-3 RNA binding family member C
GO Process (0)
GO Function (2)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
MYO1C
MMI-beta, MMIb, NMI, myr2
myosin IC
GO Process (10)
GO Function (2)
GO Component (14)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- innate immune response [TAS]
- membrane organization [TAS]
- positive regulation of cell migration [IMP]
- positive regulation of cell migration by vascular endothelial growth factor signaling pathway [IMP]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of vascular endothelial growth factor signaling pathway [IMP]
- protein targeting [IDA]
- protein targeting to membrane [IDA]
- regulation of tight junction assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basal plasma membrane [IDA]
- cytoplasm [IDA]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- filamentous actin [IDA]
- lateral plasma membrane [IDA]
- membrane [IDA]
- membrane raft [IDA]
- microvillus [IDA]
- mitochondrion [IDA]
- nucleoplasm [IDA]
- plasma membrane [IDA]
- stress fiber [IDA]
- unconventional myosin complex [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.
The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation of mRNAs through the action of a newly identified family of RNA-binding E3 ubiquitin ligases. How ubiquitin regulates mRNA decay remains unclear. Here, we identify a new role for ubiquitin in regulating deadenylation, the initial ... [more]
Nat Commun Oct. 17, 2015; 6(0);8670 [Pubmed: 26471122]
Throughput
- High Throughput
Additional Notes
- Table S1
Curated By
- BioGRID