BAIT
OTUB1
OTB1, OTU1, HSPC263
OTU deubiquitinase, ubiquitin aldehyde binding 1
GO Process (4)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSE1L
CAS, CSE1, XPO2
CSE1 chromosome segregation 1-like (yeast)
GO Process (3)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
The asparagine hydroxylase, factor inhibiting HIF (FIH), confers oxygen-dependence upon the hypoxia-inducible factor (HIF), a master regulator of the cellular adaptive response to hypoxia. Studies investigating whether asparagine hydroxylation is a general regulatory oxygen-dependent modification have identified multiple non-HIF targets for FIH. However, the functional consequences of this outside of the HIF pathway remain unclear. Here, we demonstrate that the ... [more]
PLoS Biol. Jan. 01, 2016; 14(1);e1002347 [Pubmed: 26752685]
Throughput
- High Throughput
Curated By
- BioGRID