BAIT
ERRFI1
GENE-33, MIG-6, MIG6, RALT, CTA-215D11.2
ERBB receptor feedback inhibitor 1
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- lung alveolus development [ISS]
- lung epithelium development [ISS]
- lung vasculature development [ISS]
- negative regulation of epidermal growth factor-activated receptor activity [IDA, ISS]
- negative regulation of protein autophosphorylation [IDA]
- positive regulation of Rho GTPase activity [TAS]
- regulation of keratinocyte differentiation [ISS]
- response to stress [TAS]
- skin morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CCT3
CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5, RP11-443G18.6
chaperonin containing TCP1, subunit 3 (gamma)
GO Process (3)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
We hypothesized that elucidating the interactome of epidermal growth factor receptor (EGFR) forms that are mutated in lung cancer, via global analysis of protein-protein interactions, phosphorylation, and systematically perturbing the ensuing network nodes, should offer a new, more systems-level perspective of the molecular etiology. Here, we describe an EGFR interactome of 263 proteins and offer a 14-protein core network critical ... [more]
Mol. Syst. Biol. Nov. 06, 2013; 9(0);705 [Pubmed: 24189400]
Throughput
- High Throughput
Curated By
- BioGRID