BAIT
ESRRB
DFNB35, ERR2, ERRb, ESRL2, NR3B2
estrogen-related receptor beta
GO Process (6)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [ISS]
Homo sapiens
PREY
DNAJB2
DSMA5, HSJ-1, HSJ1, HSPF3
DnaJ (Hsp40) homolog, subfamily B, member 2
GO Process (10)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of cell growth [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of inclusion body assembly [IDA]
- negative regulation of protein deubiquitination [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- protein folding [TAS]
- protein refolding [IDA]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.
We hypothesized that elucidating the interactome of epidermal growth factor receptor (EGFR) forms that are mutated in lung cancer, via global analysis of protein-protein interactions, phosphorylation, and systematically perturbing the ensuing network nodes, should offer a new, more systems-level perspective of the molecular etiology. Here, we describe an EGFR interactome of 263 proteins and offer a 14-protein core network critical ... [more]
Mol. Syst. Biol. Nov. 06, 2013; 9(0);705 [Pubmed: 24189400]
Throughput
- High Throughput
Curated By
- BioGRID