BAIT
FBXW7
AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GO Process (24)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IDA]
- lipid homeostasis [ISS]
- negative regulation of DNA endoreduplication [IMP]
- negative regulation of Notch signaling pathway [ISS]
- negative regulation of SREBP signaling pathway [ISS]
- negative regulation of hepatocyte proliferation [ISS]
- negative regulation of triglyceride biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of epidermal growth factor-activated receptor activity [IDA]
- positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- positive regulation of proteasomal protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- protein stabilization [IDA]
- protein ubiquitination [IDA]
- regulation of cell cycle G1/S phase transition [TAS]
- regulation of lipid storage [ISS]
- regulation of protein localization [ISS]
- sister chromatid cohesion [IMP]
- vasculature development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGAV
CD51, MSK8, VNRA, VTNR
integrin, alpha V
GO Process (35)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISS]
- angiogenesis [IEP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apolipoprotein A-I-mediated signaling pathway [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [IDA]
- cell growth [IMP]
- cell migration [IMP]
- cell-matrix adhesion [IDA, IMP, NAS]
- cell-substrate adhesion [IMP]
- endodermal cell differentiation [IMP]
- entry of symbiont into host cell by promotion of host phagocytosis [NAS]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- heterotypic cell-cell adhesion [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [TAS]
- negative chemotaxis [IMP]
- negative regulation of entry of bacterium into host cell [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of lipid storage [IMP]
- negative regulation of lipid transport [IMP]
- negative regulation of lipoprotein metabolic process [IMP]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IMP]
- negative regulation of macrophage derived foam cell differentiation [IMP]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell proliferation [IDA]
- regulation of apoptotic cell clearance [ISS]
- regulation of phagocytosis [IDA]
- substrate adhesion-dependent cell spreading [IDA]
- viral entry into host cell [IMP, TAS]
Gene Ontology Molecular Function- extracellular matrix binding [IDA]
- extracellular matrix protein binding [IDA]
- fibronectin binding [IDA]
- insulin-like growth factor I binding [IDA]
- opsonin binding [ISS]
- protease binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISS]
- transforming growth factor beta binding [ISS]
- voltage-gated calcium channel activity [IDA]
- extracellular matrix binding [IDA]
- extracellular matrix protein binding [IDA]
- fibronectin binding [IDA]
- insulin-like growth factor I binding [IDA]
- opsonin binding [ISS]
- protease binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISS]
- transforming growth factor beta binding [ISS]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
- alphav-beta3 integrin-IGF-1-IGF1R complex [IDA]
- cell surface [IDA, ISS]
- extracellular vesicular exosome [IDA]
- filopodium membrane [IDA]
- focal adhesion [IDA]
- integral component of plasma membrane [NAS]
- integrin alphav-beta3 complex [IDA]
- integrin alphav-beta5 complex [IDA]
- integrin alphav-beta8 complex [IDA]
- integrin complex [IDA, NAS]
- lamellipodium membrane [IDA]
- membrane [ISS]
- microvillus membrane [IDA]
- phagocytic vesicle [TAS]
- plasma membrane [IDA, TAS]
- ruffle membrane [IDA]
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.
FBW7 (F-box and WD repeat domain containing 7), also known as FBXW7 or hCDC4, is a tumor suppressor gene mutated in a broad spectrum of cancer cell types. As a component of the SCF E3 ubiquitin ligase, FBW7 is responsible for specifically recognizing phosphorylated substrates, many important for tumor progression, and targeting them for ubiquitin-mediated degradation. Although the role of ... [more]
Genetics Sep. 08, 2015; 0(0); [Pubmed: 26354767]
Throughput
- Low Throughput
Additional Notes
- shRNA knockdown in FBW7 -/-
Curated By
- BioGRID