BAIT
SLC2A4
GLUT4
solute carrier family 2 (facilitated glucose transporter), member 4
GO Process (9)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AP1M1
AP47, CLAPM2, CLTNM, MU-1A
adaptor-related protein complex 1, mu 1 subunit
GO Process (7)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A dual role of the N-terminal FQQI motif in GLUT4 trafficking.
In adipocytes, the glucose transporter GLUT4 recycles between intracellular storage vesicles and the plasma membrane. GLUT4 is internalized by a clathrin- and dynamin-dependent mechanism, and sorted into an insulin-sensitive storage compartment. Insulin stimulation leads to GLUT4 accumulation on the cell surface. The N-terminal F5QQI motif in GLUT4 has been shown previously to be required for sorting of the protein in ... [more]
Biol. Chem. Sep. 01, 2009; 390(9);883-92 [Pubmed: 19558319]
Throughput
- Low Throughput
Curated By
- BioGRID