EPS8
Gene Ontology Biological Process
- Rac protein signal transduction [IDA]
- actin crosslink formation [IDA, IMP]
- actin cytoskeleton reorganization [IMP]
- actin filament bundle assembly [IDA, IGI, IMP]
- actin polymerization-dependent cell motility [IDA]
- adult locomotory behavior [IMP]
- barbed-end actin filament capping [IDA, IMP]
- behavioral response to ethanol [IMP]
- dendritic cell migration [IMP]
- exit from mitosis [IMP]
- regulation of actin filament length [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SOS1
Gene Ontology Biological Process
- B cell homeostasis [IGI]
- Ras protein signal transduction [ISO]
- fibroblast growth factor receptor signaling pathway [IGI]
- lymphocyte homeostasis [IGI]
- neurotrophin TRK receptor signaling pathway [ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of small GTPase mediated signal transduction [ISO]
- regulation of T cell differentiation in thymus [IGI]
- regulation of T cell proliferation [IGI]
- regulation of pro-B cell differentiation [IGI]
- small GTPase mediated signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.
Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin cytoskeletal remodeling. Within this pathway, Rac is a key downstream target/effector of PI3K. However, how the signal is routed from PI3K to Rac is unclear. One possible candidate for this function is the Rac-activating complex Eps8-Abi1-Sos-1, which possesses Rac-specific guanine nucleotide ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
EPS8 SOS1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.836 | BioGRID | 2686666 |
Curated By
- BioGRID