A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Caetano C, Limbo O, Farmer S, Klier S, Dovey C, Russell P, de Bruin RA

Expression of a G1/S regulon of genes that are required for DNA replication is a ubiquitous mechanism for controlling cell proliferation; moreover, the pathological deregulated expression of E2F-regulated G1/S genes is found in every type of cancer. Cellular tolerance of deregulated G1/S transcription is surprising because this regulon includes many dosage-sensitive proteins. Here, we used the fission yeast Schizosaccharomyces pombe ... [more]

Cell Rep Dec. 24, 2014; 9(6);2279-89 [Pubmed: 25533348]

Throughput

Low Throughput

Ontology Terms

phenotype: viability (APO:0000111)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
NRM1 CTP1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Ryan CJ (2012)	High	-2.7563	BioGRID	760143

Curated By

BioGRID

Interaction Summary

NRM1

Gene Ontology Biological Process

Gene Ontology Molecular Function

chromatin binding [IDA]transcription corepressor activity [IMP]

Gene Ontology Cellular Component

CTP1