BAIT
NRM1
SPBC16A3.07c
MBF complex corepressor Nrm1
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
CIG2
cyc17, SPAPB2B4.03
G1/S-specific B-type cyclin Cig2
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- negative regulation of conjugation with cellular fusion [IMP]
- negative regulation of induction of conjugation with cellular fusion [IMP]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [IGI, IMP]
- positive regulation of protein serine/threonine kinase activity [IDA]
- signal transduction involved in G1 cell size control checkpoint [IGI]
- traversing start control point of mitotic cell cycle [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.
Expression of a G1/S regulon of genes that are required for DNA replication is a ubiquitous mechanism for controlling cell proliferation; moreover, the pathological deregulated expression of E2F-regulated G1/S genes is found in every type of cancer. Cellular tolerance of deregulated G1/S transcription is surprising because this regulon includes many dosage-sensitive proteins. Here, we used the fission yeast Schizosaccharomyces pombe ... [more]
Cell Rep Dec. 24, 2014; 9(6);2279-89 [Pubmed: 25533348]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome/plasmid maintenance (APO:0000143)
- phenotype: viability (APO:0000111)
- phenotype: protein/peptide accumulation (APO:0000149)
Additional Notes
- high levels of cig2 are critical to prevent genome instability and hyperaccumulation of cdc18
Curated By
- BioGRID