BAIT
RGA7
SPBC23G7.08c
Rho-type GTPase activating protein Rga7
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
CDC12
SPAC1F5.04c
formin Cdc12
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- actin crosslink formation [IMP]
- actin filament organization [IMP]
- actin filament polymerization [IDA, IMP]
- actin nucleation [TAS]
- actomyosin contractile ring actin filament bundle assembly [NAS]
- mitotic actomyosin contractile ring assembly [IMP]
- mitotic actomyosin contractile ring maintenance [IMP]
- protein localization to actin cytoskeleton [IMP]
- regulation of actin filament polymerization [IMP]
- transitional endoplasmic reticulum polarization at cell division site [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A role for F-BAR protein Rga7p during cytokinesis in S. pombe.
F-BAR proteins are known to participate in cytokinesis, but their mechanisms are not well understood. Here we investigated Rga7p, an Schizosaccharomyces pombe F-BAR protein with a RhoGAP domain. Localization of Rga7p to the cytokinetic cleavage furrow depends on its F-BAR domain, actin filaments, the formins Cdc12p and For3p, and the presence of a contractile ring. Rga7p is not required for ... [more]
J. Cell. Sci. Jul. 01, 2015; 128(13);2259-68 [Pubmed: 25977474]
Throughput
- Low Throughput
Ontology Terms
- phenotype: heat sensitivity (APO:0000147)
- phenotype: viability (APO:0000111)
Additional Notes
- cisphenotypic enhancing genetic interaction at 36 degrees
- monophenotypic enhancing genetic interaction at 25 degrees
Curated By
- BioGRID