BAIT
ABI1
E3B1, NAP1, Ssh3bp1, RP23-436J19.3
abl-interactor 1
GO Process (7)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HRAS
H-ras, Ha-ras, Harvey-ras, Hras-1, Hras1, Kras2, c-H-ras, c-Ha-ras, c-rasHa, ras
Harvey rat sarcoma virus oncogene
GO Process (33)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Ras protein signal transduction [ISO, TAS]
- apoptotic process [ISO]
- cell aging [IDA]
- cell cycle arrest [ISO]
- cell proliferation [IPI]
- cellular senescence [ISO]
- endocytosis [IDA]
- intrinsic apoptotic signaling pathway [IGI, IMP]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of Rho GTPase activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of neuron apoptotic process [IDA, IGI]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of wound healing [ISO]
- protein heterooligomerization [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- small GTPase mediated signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.
Class I phosphoinositide 3-kinases (PI3Ks) are implicated in many cellular responses controlled by receptor tyrosine kinases (RTKs), including actin cytoskeletal remodeling. Within this pathway, Rac is a key downstream target/effector of PI3K. However, how the signal is routed from PI3K to Rac is unclear. One possible candidate for this function is the Rac-activating complex Eps8-Abi1-Sos-1, which possesses Rac-specific guanine nucleotide ... [more]
J. Cell Biol. Jan. 06, 2003; 160(1);17-23 [Pubmed: 12515821]
Throughput
- Low Throughput
Curated By
- BioGRID