IFI16
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity [IMP]
- activation of innate immune response [IDA]
- cell proliferation [NAS]
- cellular response to glucose starvation [IDA]
- cellular response to ionizing radiation [IDA]
- defense response to virus [IMP]
- hemopoiesis [NAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- monocyte differentiation [IDA]
- myeloid cell differentiation [NAS]
- negative regulation of DNA binding [IDA]
- negative regulation of cysteine-type endopeptidase activity [IDA]
- negative regulation of innate immune response [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of cytokine production [TAS]
- positive regulation of interleukin-1 beta production [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- regulation of autophagy [IEP]
- regulation of gene expression, epigenetic [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [IDA]
- double-stranded DNA binding [IDA]
- identical protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter binding [IDA]
- double-stranded DNA binding [IDA]
- identical protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IDA]
BRCA1
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [TAS]
- DNA repair [TAS]
- G2 DNA damage checkpoint [IMP]
- androgen receptor signaling pathway [NAS]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to tumor necrosis factor [IMP]
- chordate embryonic development [IBA]
- chromosome segregation [IMP]
- dosage compensation by inactivation of X chromosome [IBA]
- double-strand break repair [IMP, TAS]
- double-strand break repair via homologous recombination [IDA, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- negative regulation of centriole replication [NAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fatty acid biosynthetic process [IMP]
- negative regulation of histone H3-K9 methylation [IDA]
- negative regulation of histone acetylation [IBA]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of DNA repair [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of histone H3-K9 acetylation [IDA]
- positive regulation of histone H4-K16 acetylation [IDA]
- positive regulation of histone H4-K20 methylation [IDA]
- positive regulation of histone acetylation [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [NAS, TAS]
- positive regulation vascular endothelial growth factor production [IMP]
- postreplication repair [IDA]
- protein K6-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination [IDA]
- regulation of apoptotic process [TAS]
- regulation of cell proliferation [TAS]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription from RNA polymerase III promoter [TAS]
- response to estrogen [IDA]
- response to ionizing radiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses.
The innate immune system pattern recognition receptors (PRR) are the first line of host defenses recognizing the various pathogen- or danger-associated molecular patterns and eliciting defenses by regulating the production of pro-inflammatory cytokines such as IL-1β, IL-18 or interferon β (IFN-β). NOD-like receptors (NLRs) and AIM2-like receptors (ALRs) are cytoplasmic inflammasome sensors of foreign molecules, including DNA. IFI16, a sequence-independent ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BRCA1 IFI16 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| BRCA1 IFI16 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IFI16 BRCA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IFI16 BRCA1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 1520541 |
Curated By
- BioGRID