BAIT
TXN
TRDX, TRX, TRX1, RP11-427L11.1
thioredoxin
GO Process (17)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- activation of protein kinase B activity [IC]
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- negative regulation of hydrogen peroxide-induced cell death [IGI]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- oxidation-reduction process [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of protein kinase B signaling [IC]
- regulation of protein import into nucleus, translocation [IDA]
- response to radiation [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NCF4
NCF, P40PHOX, SH3PXD4, CTA-833B7.1
neutrophil cytosolic factor 4, 40kDa
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- immune response [TAS]
- interaction with host [TAS]
- oxidation-reduction process [TAS]
- phagosome maturation [TAS]
- positive regulation of catalytic activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system.
Thioredoxin (TRX) has disulfide reducing activity and is reported to be involved in various cellular functions including the promotion of cell growth and apoptosis. To help understand the molecular mechanism through which TRX is involved in immunological systems, we screened a cDNA library derived from a B-cell population of Epstein-Barr virus-transformed human peripheral blood lymhocyte for TRX binding proteins by ... [more]
Immunol. Lett. May. 03, 1999; 68(1);155-9 [Pubmed: 10397171]
Throughput
- Low Throughput
Curated By
- BioGRID