BAIT
HSD17B10
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, RP3-339A18.2
hydroxysteroid (17-beta) dehydrogenase 10
GO Process (4)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CST3
CysC, RP23-250M11.9
cystatin C
GO Process (11)
GO Function (5)
GO Component (15)
Gene Ontology Biological Process
- defense response [ISO]
- extracellular fibril organization [ISO]
- negative regulation of cell death [ISO]
- negative regulation of elastin catabolic process [ISO]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of peptidase activity [ISO]
- negative regulation of proteolysis [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of cell proliferation [ISO]
- regulation of programmed cell death [ISO]
- response to oxidative stress [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISO]
- basement membrane [ISO]
- cell projection [ISO]
- contractile fiber [ISO]
- cytoplasm [ISO]
- endoplasmic reticulum [ISO]
- extracellular region [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- lysosome [ISO]
- multivesicular body [ISO]
- neuronal cell body [ISO]
- nuclear membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
Proteins involved in mitochondrial metabolic pathways engage in functionally relevant multi-enzyme complexes. We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulinism in SCHAD-deficient patients and adding SCHAD to the list of mitochondrial proteins capable of forming functional, multi-pathway complexes. In this work, we provide evidence of SCHAD's involvement ... [more]
PLoS ONE Apr. 13, 2012; 7(4);e35048 [Pubmed: 22496890]
Throughput
- Low Throughput
Curated By
- BioGRID