BAIT
HSD17B10
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, RP3-339A18.2
hydroxysteroid (17-beta) dehydrogenase 10
GO Process (4)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GLUL
GS, Glns
glutamate-ammonia ligase (glutamine synthetase)
GO Process (10)
GO Function (8)
GO Component (14)
Gene Ontology Biological Process
- ammonia assimilation cycle [ISO]
- cell proliferation [ISO]
- cellular response to starvation [IEP]
- glutamate metabolic process [ISO]
- glutamine biosynthetic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein homooligomerization [ISO]
- response to glucose [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon terminus [ISO]
- cell body [IDA]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- glial cell projection [IDA]
- intracellular membrane-bounded organelle [ISO]
- mitochondrion [IDA]
- myelin sheath [IDA]
- neuron projection [ISO]
- nucleus [ISO]
- perikaryon [ISO]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
Proteins involved in mitochondrial metabolic pathways engage in functionally relevant multi-enzyme complexes. We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulinism in SCHAD-deficient patients and adding SCHAD to the list of mitochondrial proteins capable of forming functional, multi-pathway complexes. In this work, we provide evidence of SCHAD's involvement ... [more]
PLoS ONE Apr. 13, 2012; 7(4);e35048 [Pubmed: 22496890]
Throughput
- Low Throughput
Curated By
- BioGRID