BAIT
HSD17B10
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, RP3-339A18.2
hydroxysteroid (17-beta) dehydrogenase 10
GO Process (4)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CAT
2210418N07, Cas-1, Cas1, Cs-1, RP23-266F3.2
catalase
GO Process (19)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- UV protection [ISO]
- aerobic respiration [IMP]
- cholesterol metabolic process [IMP]
- hemoglobin metabolic process [IMP]
- hydrogen peroxide catabolic process [IDA, IMP, ISO]
- kidney development [ISO]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of apoptotic process [ISO]
- osteoblast differentiation [ISO]
- oxidation-reduction process [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- protein homotetramerization [ISO]
- protein tetramerization [ISO]
- response to hypoxia [ISO]
- response to oxidative stress [IDA, IMP, ISO]
- response to reactive oxygen species [ISO]
- triglyceride metabolic process [IMP]
- ureteric bud development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- lysosome [ISO]
- membrane [ISO]
- mitochondrial intermembrane space [ISO]
- mitochondrion [IDA]
- peroxisomal membrane [IDA]
- peroxisome [IDA, ISO]
- plasma membrane [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
Proteins involved in mitochondrial metabolic pathways engage in functionally relevant multi-enzyme complexes. We previously described an interaction between short-chain 3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) and glutamate dehydrogenase (GDH) explaining the clinical phenotype of hyperinsulinism in SCHAD-deficient patients and adding SCHAD to the list of mitochondrial proteins capable of forming functional, multi-pathway complexes. In this work, we provide evidence of SCHAD's involvement ... [more]
PLoS ONE Apr. 13, 2012; 7(4);e35048 [Pubmed: 22496890]
Throughput
- Low Throughput
Curated By
- BioGRID